Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects.

Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D; Wölfel, Silke; Gekara, Nelson O; Kröger, Andrea; Överby, Anna K

dc.contributor.author	Lindqvist, Richard
dc.contributor.author	Mundt, Filip
dc.contributor.author	Gilthorpe, Jonathan D
dc.contributor.author	Wölfel, Silke
dc.contributor.author	Gekara, Nelson O
dc.contributor.author	Kröger, Andrea
dc.contributor.author	Överby, Anna K
dc.date.accessioned	2016-11-30T14:43:27Z
dc.date.available	2016-11-30T14:43:27Z
dc.date.issued	2016-10-24
dc.identifier.citation	Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects. 2016, 13 (1):277 J Neuroinflammation	en
dc.identifier.issn	1742-2094
dc.identifier.pmid	27776548
dc.identifier.doi	10.1186/s12974-016-0748-7
dc.identifier.uri	http://hdl.handle.net/10033/620609
dc.description.abstract	Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents of severe brain-related diseases including meningitis, encephalitis, and microcephaly. We have previously shown that local type I interferon response within the central nervous system (CNS) is involved in the protection of mice against tick-borne flavivirus infection. However, the cells responsible for mounting this protective response are not defined.
dc.language	ENG
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects.
dc.type	Article	en
dc.contributor.department	Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.	en
dc.identifier.journal	Journal of neuroinflammation	en
refterms.dateFOA	2018-06-13T03:57:02Z
html.description.abstract	Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents of severe brain-related diseases including meningitis, encephalitis, and microcephaly. We have previously shown that local type I interferon response within the central nervous system (CNS) is involved in the protection of mice against tick-borne flavivirus infection. However, the cells responsible for mounting this protective response are not defined.