Browsing publications of the research group drug delivery ([HIPS] DDEL) by Subjects
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The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB.We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.