Biodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency.
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Issue Date
2016-10-03
Metadata
Show full item recordAbstract
Regioselective oxidation of water-soluble starch and conversion with alkyl diamines resulted in defined cationic starch derivatives. Those were assessed in their potential for polyplex formation, biocompatibility, and transfection efficacy. The new polymers have the advantage of being biodegradable, being not cytotoxic at rather high concentrations (LC50 > 400 μg/ml) for C2 substitution, and reach transfection efficiencies comparable to commercial transfection reagents. The polymer with the highest transfection efficacy is a C12 substituted polymer (degree of substitution = 30 %) at N/P 3. The LC50 value of that highly modified polymer is still one order of magnitude lower than that of PEI 25 kDa.Citation
Biodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency. 2016: Drug Deliv Transl ResAffiliation
Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS),Saarland Universitätscampus E8.1, 66123 Saarbrücken, Germany.PubMed ID
27699593Type
ArticleISSN
2190-3948ae974a485f413a2113503eed53cd6c53
10.1007/s13346-016-0333-8
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
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