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dc.contributor.authorThiele, Carolin
dc.contributor.authorLoretz, Brigitta
dc.contributor.authorLehr, Claus Michael
dc.date.accessioned2016-12-01T09:22:46Z
dc.date.available2016-12-01T09:22:46Z
dc.date.issued2016-10-03
dc.identifier.citationBiodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency. 2016: Drug Deliv Transl Resen
dc.identifier.issn2190-3948
dc.identifier.pmid27699593
dc.identifier.doi10.1007/s13346-016-0333-8
dc.identifier.urihttp://hdl.handle.net/10033/620615
dc.description.abstractRegioselective oxidation of water-soluble starch and conversion with alkyl diamines resulted in defined cationic starch derivatives. Those were assessed in their potential for polyplex formation, biocompatibility, and transfection efficacy. The new polymers have the advantage of being biodegradable, being not cytotoxic at rather high concentrations (LC50 > 400 μg/ml) for C2 substitution, and reach transfection efficiencies comparable to commercial transfection reagents. The polymer with the highest transfection efficacy is a C12 substituted polymer (degree of substitution = 30 %) at N/P 3. The LC50 value of that highly modified polymer is still one order of magnitude lower than that of PEI 25 kDa.
dc.languageENG
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleBiodegradable starch derivatives with tunable charge density-synthesis, characterization, and transfection efficiency.
dc.typeArticleen
dc.contributor.departmentHelmholtz-Institute for Pharmaceutical Research Saarland (HIPS),Saarland Universitätscampus E8.1, 66123 Saarbrücken, Germany.en
dc.identifier.journalDrug delivery and translational researchen
refterms.dateFOA2017-10-03T00:00:00Z
html.description.abstractRegioselective oxidation of water-soluble starch and conversion with alkyl diamines resulted in defined cationic starch derivatives. Those were assessed in their potential for polyplex formation, biocompatibility, and transfection efficacy. The new polymers have the advantage of being biodegradable, being not cytotoxic at rather high concentrations (LC50 > 400 μg/ml) for C2 substitution, and reach transfection efficiencies comparable to commercial transfection reagents. The polymer with the highest transfection efficacy is a C12 substituted polymer (degree of substitution = 30 %) at N/P 3. The LC50 value of that highly modified polymer is still one order of magnitude lower than that of PEI 25 kDa.


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