Browsing publications of the research group of microbial natural substances([HIPS]MINS) by Authors
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The actin targeting compound Chondramide inhibits breast cancer metastasis via reduction of cellular contractility.Menhofer, Magdalena H; Kubisch, Rebekka; Schreiner, Laura; Zorn, Matthias; Foerster, Florian; Mueller, Rolf; Raedler, Joachim O; Wagner, Ernst; Vollmar, Angelika M; Zahler, Stefan; et al. (2014)A major player in the process of metastasis is the actin cytoskeleton as it forms key structures in both invasion mechanisms, mesenchymal and amoeboid migration. We tested the actin binding compound Chondramide as potential anti-metastatic agent.