Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs.

Siddharta, Anindya; Pfaender, Stephanie; Malassa, Angelina; Doerrbecker, Juliane; Anggakusuma; Engelmann, Michael; Nugraha, Boya; Steinmann, Joerg; Todt, Daniel; Vondran, Florian W R; Mateu-Gelabert, Pedro; Goffinet, Christine; Steinmann, Eike

dc.contributor.author	Siddharta, Anindya
dc.contributor.author	Pfaender, Stephanie
dc.contributor.author	Malassa, Angelina
dc.contributor.author	Doerrbecker, Juliane
dc.contributor.author	Anggakusuma
dc.contributor.author	Engelmann, Michael
dc.contributor.author	Nugraha, Boya
dc.contributor.author	Steinmann, Joerg
dc.contributor.author	Todt, Daniel
dc.contributor.author	Vondran, Florian W R
dc.contributor.author	Mateu-Gelabert, Pedro
dc.contributor.author	Goffinet, Christine
dc.contributor.author	Steinmann, Eike
dc.date.accessioned	2016-12-05T15:14:17Z
dc.date.available	2016-12-05T15:14:17Z
dc.date.issued	2016-11-18
dc.identifier.citation	Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs. 2016, 6:36619 Sci Rep	en
dc.identifier.issn	2045-2322
dc.identifier.pmid	27857152
dc.identifier.doi	10.1038/srep36619
dc.identifier.uri	http://hdl.handle.net/10033/620624
dc.description.abstract	Hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1) transmissions among people who inject drugs (PWID) continue to pose a challenging global health problem. Here, we aimed to analyse a universally applicable inactivation procedure, namely microwave irradiation, as a safe and effective method to reduce the risk of viral transmission. The exposure of HCV from different genotypes to microwave irradiation resulted in a significant reduction of viral infectivity. Furthermore, microwave irradiation reduced viral infectivity of HIV-1 and of HCV/HIV-1 suspensions indicating that this inactivation may be effective at preventing co-infections. To translate microwave irradiation as prevention method to used drug preparation equipment, we could further show that HCV as well as HIV-1 infectivity could be abrogated in syringes and filters. This study demonstrates the power of microwave irradiation for the reduction of viral transmission and establishment of this safety strategy could help reduce the transmission of blood-borne viruses.
dc.language.iso	en	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs.	en
dc.type	Article	en
dc.identifier.journal	Scientific reports	en
refterms.dateFOA	2018-06-13T02:39:44Z
html.description.abstract	Hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1) transmissions among people who inject drugs (PWID) continue to pose a challenging global health problem. Here, we aimed to analyse a universally applicable inactivation procedure, namely microwave irradiation, as a safe and effective method to reduce the risk of viral transmission. The exposure of HCV from different genotypes to microwave irradiation resulted in a significant reduction of viral infectivity. Furthermore, microwave irradiation reduced viral infectivity of HIV-1 and of HCV/HIV-1 suspensions indicating that this inactivation may be effective at preventing co-infections. To translate microwave irradiation as prevention method to used drug preparation equipment, we could further show that HCV as well as HIV-1 infectivity could be abrogated in syringes and filters. This study demonstrates the power of microwave irradiation for the reduction of viral transmission and establishment of this safety strategy could help reduce the transmission of blood-borne viruses.