• TLR8 regulation of LILRA3 in monocytes is abrogated in human immunodeficiency virus infection and correlates to CD4 counts and virus loads.

      Low, Hui Zhi; Ahrenstorf, Gerrit; Pommerenke, Claudia; Habermann, Nadine; Schughart, Klaus; Ordóñez, David; Stripecke, Renata; Wilk, Esther; Witte, Torsten; Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. (2016)
      LILRA3 is an immunostimulatory molecule which can conditionally induce the proliferation of cytotoxic cells. LILRA3 has a deletion genotype which is associated with multiple immune disorders. In this study, we wanted to analyze the regulation of LILRA3 and its significance in the context of HIV infection.