Browsing Department of molecular bacteriology (MOBA) by Journal
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Assessment of an APOBEC3B truncating mutation, c.783delG, in patients with breast cancer.APOBEC3B belongs to the family of DNA-editing enzymes. A copy number variant targeting the genomic APOBEC3A-APOBEC3B locus has a significant impact on breast cancer risk, but the relative contribution of APOBEC3B is uncertain. In this study, we investigate a loss-of-function mutation that selectively targets APOBEC3B, for its association with breast cancer risk.