• A simple and efficient method for the preparation of 5-hydroxy-3-acyltetramic acids.

      Trenner, Johanna; Prusov, Evgeny V; Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany. (2015)
      Oxidation of the bisenolates of 3-acyltetramic acid to the corresponding 5-hydroxylated compounds using molecular oxygen is reported. The deprotection of the resulting compounds was also achieved.
    • Synthesis of the spiroketal core of integramycin.

      Prusov, Evgeny V; Department of Medicinal Chemistry, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany (2013)
      A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The effects of different protecting groups on the spiroketalization step were also investigated.
    • Total synthesis of antibiotics: recent achievements, limitations, and perspectives.

      Prusov, Evgeny V; Helmholtz Zentrum für Infektionsforschung, Braunschweig, Germany. Evgeny.Prusov@helmholtz-hzi.de (2013-04)
      Several recently accomplished total syntheses of antibiotic natural products were summarized in this review in order to present current trends in this area of research. Compounds from different substance classes, including polyketide, depsipeptide, polyketide-polypeptide hybrid, and saccharide, were chosen to demonstrate the advancement in both chemical methodology and corresponding synthetic strategy.