Browsing publications of the department medicinal chemistry (MCH) by Journal
Now showing items 1-2 of 2
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A simple and efficient method for the preparation of 5-hydroxy-3-acyltetramic acids.Oxidation of the bisenolates of 3-acyltetramic acid to the corresponding 5-hydroxylated compounds using molecular oxygen is reported. The deprotection of the resulting compounds was also achieved.
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Synthesis of the spiroketal core of integramycin.A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The effects of different protecting groups on the spiroketalization step were also investigated.
