Browsing Department of Drug design and optimization ([HIPS]DDOP) by Subjects
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Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma.MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC.