Acute and chronic infections with nonprimate hepacivirus in young horses.

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Authors
Gather, Theresa
Walter, Stephanie
Pfaender, Stephanie
Todt, Daniel
Feige, Karsten
Steinmann, Eike cc
Cavalleri, Jessika M V
Issue Date
2016-09-22

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Abstract
The recently discovered nonprimate hepacivirus (NPHV) naturally infects horses and is the closest known homolog of hepatitis C virus to date. Within a follow-up study acute field infections were monitored in four young Thoroughbred horses until the ages of 12-13 months. Serum samples were analyzed for the presence of NPHV RNA and anti-NPHV NS3 antibodies and liver specific parameters were evaluated. The four young horses were not able to clear infection, but remained chronically infected for the entire monitored time period despite the presence of NPHV specific antibodies.
Citation
Acute and chronic infections with nonprimate hepacivirus in young horses. 2016, 47 (1):97 Vet. Res.
Affiliation
Twincore Centre of Experimental and Clinical Infection Research; a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover 30625, Germany.
Journal
Veterinary research
URI
http://hdl.handle.net/10033/620664
DOI
10.1186/s13567-016-0381-6
PubMed ID
27659317
Type
Article
Language
en
ISSN
1297-9716
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http://creativecommons.org/licenses/by-nc-sa/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/