• Gene expression profiles of T cells from hepatitis E virus infected patients in acute and resolving phase.

      TrehanPati, Nirupma; Sukriti, Sukriti; Geffers, Robert; Hissar, Syed; Riese, Peggy; Toepfer, Tanja; Guzman, Carlos A; Sarin, Shiv Kumar; Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, 110 070, New Delhi, India. trehanpati@gmail.com (2011-06)
      Approximately 50% of acute viral hepatitis in young adults and in pregnant women is due to hepatitis E virus (HEV) infection in developing countries. T cell-mediated immune injury probably plays a key role in the pathogenesis of acute hepatitis illness. However, there is a paucity of data on the global gene expression programs activated on T cells, which are subsequently responsible for T cell recruitment to the liver and triggering of immune injury.