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    Multiple antibody targets on herpes B glycoproteins B and D identified by screening sera of infected rhesus macaques with peptide microarrays.

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    Authors
    Hotop, Sven-Kevin
    Abd El Wahed, Ahmed
    Beutling, Ulrike
    Jentsch, Dieter
    Motzkus, Dirk
    Frank, Ronald
    Hunsmann, Gerhard
    Stahl-Hennig, Christiane
    Fritz, Hans-Joachim
    Issue Date
    2014
    
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    Abstract
    Herpes B virus (or Herpesvirus simiae or Macacine herpesvirus 1) is endemic in many populations of macaques, both in the wild and in captivity. The virus elicits only mild clinical symptoms (if any) in monkeys, but can be transmitted by various routes, most commonly via bites, to humans where it causes viral encephalitis with a high mortality rate. Hence, herpes B constitutes a considerable occupational hazard for animal caretakers, veterinarians and laboratory personnel. Efforts are therefore being made to reduce the risk of zoonotic infection and to improve prognosis after accidental exposure. Among the measures envisaged are serological surveillance of monkey colonies and specific diagnosis of herpes B zoonosis against a background of antibodies recognizing the closely related human herpes simplex virus (HSV). 422 pentadecapeptides covering, in an overlapping fashion, the entire amino acid sequences of herpes B proteins gB and gD were synthesized and immobilized on glass slides. Antibodies present in monkey sera that bind to subsets of the peptide collection were detected by microserological techniques. With 42 different rhesus macaque sera, 114 individual responses to 18 different antibody target regions (ATRs) were recorded, 17 of which had not been described earlier. This finding may pave the way for a peptide-based, herpes B specific serological diagnostic test.
    Citation
    Multiple antibody targets on herpes B glycoproteins B and D identified by screening sera of infected rhesus macaques with peptide microarrays. 2014, 9 (1):e86857 PLoS ONE
    Affiliation
    Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
    Journal
    PloS one
    URI
    http://hdl.handle.net/10033/620740
    DOI
    10.1371/journal.pone.0086857
    PubMed ID
    24497986
    Type
    Article
    Language
    en
    ISSN
    1932-6203
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0086857
    Scopus Count
    Collections
    Publications of the research group Chemical Biology (CBIO)

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