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Authors
Ghanem, AlexanderMayer, Daniel
Chase, Geoffrey
Tegge, Werner
Frank, Ronald
Kochs, Georg
García-Sastre, Adolfo
Schwemmle, Martin
Issue Date
2007-07
Metadata
Show full item recordAbstract
The assembly of the polymerase complex of influenza A virus from the three viral polymerase subunits PB1, PB2, and PA is required for viral RNA synthesis. We show that peptides which specifically bind to the protein-protein interaction domains in the subunits responsible for complex formation interfere with polymerase complex assembly and inhibit viral replication. Specifically, we provide evidence that a 25-amino-acid peptide corresponding to the PA-binding domain of PB1 blocks the polymerase activity of influenza A virus and inhibits viral spread. Targeting polymerase subunit interactions therefore provides a novel strategy to develop antiviral compounds against influenza A virus or other viruses.Citation
Peptide-mediated interference with influenza A virus polymerase. 2007, 81 (14):7801-4 J. Virol.Affiliation
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.Journal
Journal of virologyPubMed ID
17494067Type
ArticleLanguage
enISSN
0022-538Xae974a485f413a2113503eed53cd6c53
10.1128/JVI.00724-07
Scopus Count