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    Peptide-mediated interference with influenza A virus polymerase.

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    Authors
    Ghanem, Alexander
    Mayer, Daniel
    Chase, Geoffrey
    Tegge, Werner
    Frank, Ronald
    Kochs, Georg
    García-Sastre, Adolfo
    Schwemmle, Martin
    Issue Date
    2007-07
    
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    Abstract
    The assembly of the polymerase complex of influenza A virus from the three viral polymerase subunits PB1, PB2, and PA is required for viral RNA synthesis. We show that peptides which specifically bind to the protein-protein interaction domains in the subunits responsible for complex formation interfere with polymerase complex assembly and inhibit viral replication. Specifically, we provide evidence that a 25-amino-acid peptide corresponding to the PA-binding domain of PB1 blocks the polymerase activity of influenza A virus and inhibits viral spread. Targeting polymerase subunit interactions therefore provides a novel strategy to develop antiviral compounds against influenza A virus or other viruses.
    Citation
    Peptide-mediated interference with influenza A virus polymerase. 2007, 81 (14):7801-4 J. Virol.
    Affiliation
    Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
    Journal
    Journal of virology
    URI
    http://hdl.handle.net/10033/620741
    DOI
    10.1128/JVI.00724-07
    PubMed ID
    17494067
    Type
    Article
    Language
    en
    ISSN
    0022-538X
    ae974a485f413a2113503eed53cd6c53
    10.1128/JVI.00724-07
    Scopus Count
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    Publications of the research group Chemical Biology (CBIO)

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