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    Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the hepatitis B surface antigen.

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    Lünsdorf et al.pdf
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    Authors
    Lünsdorf, Heinrich
    Gurramkonda, Chandrasekhar
    Adnan, Ahmad
    Khanna, Navin
    Rinas, Ursula
    Issue Date
    2011-06-26
    
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    Abstract
    A protective immune response against Hepatitis B infection can be obtained through the administration of a single viral polypeptide, the Hepatitis B surface antigen (HBsAg). Thus, the Hepatitis B vaccine is generated through the utilization of recombinant DNA technology, preferentially by using yeast-based expression systems. However, the polypeptide needs to assemble into spherical particles, so-called virus-like particles (VLPs), to elicit the required protective immune response. So far, no clear evidence has been presented showing whether HBsAg assembles in vivo inside the yeast cell into VLPs or later in vitro during down-stream processing and purification.
    Citation
    Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the hepatitis B surface antigen. 2011, 10:48 Microb. Cell Fact.
    Affiliation
    Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
    Journal
    Microbial cell factories
    URI
    http://hdl.handle.net/10033/620742
    DOI
    10.1186/1475-2859-10-48
    PubMed ID
    21703024
    Type
    Article
    Language
    en
    ISSN
    1475-2859
    ae974a485f413a2113503eed53cd6c53
    10.1186/1475-2859-10-48
    Scopus Count
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    publications of the research group vaccinology and applied microbiology (VAC)

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