In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome.

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Authors
Todt, Daniel
Gisa, Anett
Radonic, Aleksandar
Nitsche, Andreas
Behrendt, Patrick
Suneetha, Pothakamuri Venkata
Pischke, Sven
Bremer, Birgit
Brown, Richard J P
Manns, Michael P
Issue Date
2016-10

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Abstract
Hepatitis E virus (HEV) infection can take chronic courses in immunocompromised patients potentially leading to liver cirrhosis and liver failure. Ribavirin (RBV) is currently the only treatment option for many patients, but treatment failure can occur which has been associated with the appearance of a distinct HEV polymerase mutant (G1634R). Here, we performed a detailed analysis of HEV viral intrahost evolution during chronic hepatitis E infections.
Citation
In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome. 2016, 65 (10):1733-43 Gut
Affiliation
Twincore Centre of Experimental and Clinical Infection Research; a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover 30625, Germany.
Journal
Gut
URI
http://hdl.handle.net/10033/620804
DOI
10.1136/gutjnl-2015-311000
PubMed ID
27222534
Type
Article
Language
en
ISSN
1468-3288
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http://creativecommons.org/licenses/by-nc-sa/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/