In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome.
dc.contributor.author | Todt, Daniel | |
dc.contributor.author | Gisa, Anett | |
dc.contributor.author | Radonic, Aleksandar | |
dc.contributor.author | Nitsche, Andreas | |
dc.contributor.author | Behrendt, Patrick | |
dc.contributor.author | Suneetha, Pothakamuri Venkata | |
dc.contributor.author | Pischke, Sven | |
dc.contributor.author | Bremer, Birgit | |
dc.contributor.author | Brown, Richard J P | |
dc.contributor.author | Manns, Michael P | |
dc.contributor.author | Cornberg, Markus | |
dc.contributor.author | Bock, C Thomas | |
dc.contributor.author | Steinmann, Eike | |
dc.contributor.author | Wedemeyer, Heiner | |
dc.date.accessioned | 2017-02-03T09:50:39Z | |
dc.date.available | 2017-02-03T09:50:39Z | |
dc.date.issued | 2016-10 | |
dc.identifier.citation | In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome. 2016, 65 (10):1733-43 Gut | en |
dc.identifier.issn | 1468-3288 | |
dc.identifier.pmid | 27222534 | |
dc.identifier.doi | 10.1136/gutjnl-2015-311000 | |
dc.identifier.uri | http://hdl.handle.net/10033/620804 | |
dc.description.abstract | Hepatitis E virus (HEV) infection can take chronic courses in immunocompromised patients potentially leading to liver cirrhosis and liver failure. Ribavirin (RBV) is currently the only treatment option for many patients, but treatment failure can occur which has been associated with the appearance of a distinct HEV polymerase mutant (G1634R). Here, we performed a detailed analysis of HEV viral intrahost evolution during chronic hepatitis E infections. | |
dc.language.iso | en | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.title | In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome. | en |
dc.type | Article | en |
dc.contributor.department | Twincore Centre of Experimental and Clinical Infection Research; a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover 30625, Germany. | en |
dc.identifier.journal | Gut | en |
refterms.dateFOA | 2018-06-12T21:41:53Z | |
html.description.abstract | Hepatitis E virus (HEV) infection can take chronic courses in immunocompromised patients potentially leading to liver cirrhosis and liver failure. Ribavirin (RBV) is currently the only treatment option for many patients, but treatment failure can occur which has been associated with the appearance of a distinct HEV polymerase mutant (G1634R). Here, we performed a detailed analysis of HEV viral intrahost evolution during chronic hepatitis E infections. |