Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection.
dc.contributor.author | Bahgat, Mahmoud M | |
dc.contributor.author | Błazejewska, Paulina | |
dc.contributor.author | Schughart, Klaus | |
dc.date.accessioned | 2017-02-15T12:47:51Z | |
dc.date.available | 2017-02-15T12:47:51Z | |
dc.date.issued | 2011-01-20 | |
dc.identifier.citation | Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection. 2011, 8:27 Virol. J. | en |
dc.identifier.issn | 1743-422X | |
dc.identifier.pmid | 21251300 | |
dc.identifier.doi | 10.1186/1743-422X-8-27 | |
dc.identifier.uri | http://hdl.handle.net/10033/620819 | |
dc.description.abstract | Host serine proteases are essential for the influenza virus life cycle because the viral haemagglutinin is synthesized as a precursor which requires proteolytic maturation. Therefore, we studied the activity and expression of serine proteases in lungs from mice infected with influenza and evaluated the effect of serine protease inhibitors on virus replication both in cell culture and in infected mice. | |
dc.language.iso | en | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject.mesh | Animals | en |
dc.subject.mesh | Body Weight | en |
dc.subject.mesh | Cell Line | en |
dc.subject.mesh | Epithelial Cells | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Influenza A Virus, H1N1 Subtype | en |
dc.subject.mesh | Influenza A Virus, H7N7 Subtype | en |
dc.subject.mesh | Lung | en |
dc.subject.mesh | Mice | en |
dc.subject.mesh | Mice, Inbred C57BL | en |
dc.subject.mesh | Mice, Inbred DBA | en |
dc.subject.mesh | Orthomyxoviridae Infections | en |
dc.subject.mesh | Serine Proteases | en |
dc.subject.mesh | Serine Proteinase Inhibitors | en |
dc.subject.mesh | Virus Replication | en |
dc.title | Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection. | en |
dc.type | Article | en |
dc.contributor.department | Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany. | en |
dc.identifier.journal | Virology journal | en |
refterms.dateFOA | 2018-06-13T01:16:20Z | |
html.description.abstract | Host serine proteases are essential for the influenza virus life cycle because the viral haemagglutinin is synthesized as a precursor which requires proteolytic maturation. Therefore, we studied the activity and expression of serine proteases in lungs from mice infected with influenza and evaluated the effect of serine protease inhibitors on virus replication both in cell culture and in infected mice. |