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dc.contributor.authorBahgat, Mahmoud M
dc.contributor.authorBłazejewska, Paulina
dc.contributor.authorSchughart, Klaus
dc.date.accessioned2017-02-15T12:47:51Z
dc.date.available2017-02-15T12:47:51Z
dc.date.issued2011-01-20
dc.identifier.citationInhibition of lung serine proteases in mice: a potentially new approach to control influenza infection. 2011, 8:27 Virol. J.en
dc.identifier.issn1743-422X
dc.identifier.pmid21251300
dc.identifier.doi10.1186/1743-422X-8-27
dc.identifier.urihttp://hdl.handle.net/10033/620819
dc.description.abstractHost serine proteases are essential for the influenza virus life cycle because the viral haemagglutinin is synthesized as a precursor which requires proteolytic maturation. Therefore, we studied the activity and expression of serine proteases in lungs from mice infected with influenza and evaluated the effect of serine protease inhibitors on virus replication both in cell culture and in infected mice.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimalsen
dc.subject.meshBody Weighten
dc.subject.meshCell Lineen
dc.subject.meshEpithelial Cellsen
dc.subject.meshHumansen
dc.subject.meshInfluenza A Virus, H1N1 Subtypeen
dc.subject.meshInfluenza A Virus, H7N7 Subtypeen
dc.subject.meshLungen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred C57BLen
dc.subject.meshMice, Inbred DBAen
dc.subject.meshOrthomyxoviridae Infectionsen
dc.subject.meshSerine Proteasesen
dc.subject.meshSerine Proteinase Inhibitorsen
dc.subject.meshVirus Replicationen
dc.titleInhibition of lung serine proteases in mice: a potentially new approach to control influenza infection.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalVirology journalen
refterms.dateFOA2018-06-13T01:16:20Z
html.description.abstractHost serine proteases are essential for the influenza virus life cycle because the viral haemagglutinin is synthesized as a precursor which requires proteolytic maturation. Therefore, we studied the activity and expression of serine proteases in lungs from mice infected with influenza and evaluated the effect of serine protease inhibitors on virus replication both in cell culture and in infected mice.


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