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dc.contributor.authorEffenberger-Neidnicht, Katharina
dc.contributor.authorBreyer, Sandra
dc.contributor.authorMahal, Katharina
dc.contributor.authorSasse, Florenz
dc.contributor.authorSchobert, Rainer
dc.date.accessioned2017-02-23T10:29:00Z
dc.date.available2017-02-23T10:29:00Z
dc.date.issued2012-01
dc.identifier.citationModification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence. 2012, 69 (1):85-90 Cancer Chemother. Pharmacol.en
dc.identifier.issn1432-0843
dc.identifier.pmid21607555
dc.identifier.doi10.1007/s00280-011-1675-z
dc.identifier.urihttp://hdl.handle.net/10033/620839
dc.description.abstractDoxorubicin (1) is commonly used in the treatment of a wide range of cancers. Some N-acylhydrazones of 1 were previously found to have an improved tumour and organ selectivity. In order to clarify the molecular basis for this effect, the cellular uptake into various cancer cells and the localisation in PtK(2) potoroo kidney cells of 1 and its N-acylhydrazones derived from heptadecanoic acid (2) and 11-(menthoxycarbonyl)undecanoic acid (3) were studied drawing on their intrinsic fluorescence.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimalsen
dc.subject.meshAntibiotics, Antineoplasticen
dc.subject.meshCell Line, Tumoren
dc.subject.meshCell Membraneen
dc.subject.meshCells, Cultureden
dc.subject.meshDoxorubicinen
dc.subject.meshDrug Resistance, Multipleen
dc.subject.meshDrug Resistance, Neoplasmen
dc.subject.meshEpithelial Cellsen
dc.subject.meshFemaleen
dc.subject.meshFluorometryen
dc.subject.meshHumansen
dc.subject.meshHydrazonesen
dc.subject.meshKidneyen
dc.subject.meshLysosomesen
dc.subject.meshMaleen
dc.subject.meshMicroscopy, Fluorescenceen
dc.subject.meshNeoplasmsen
dc.subject.meshPotoroidaeen
dc.subject.meshTime Factorsen
dc.titleModification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence.en
dc.typeArticleen
dc.identifier.journalCancer chemotherapy and pharmacologyen
refterms.dateFOA2018-06-13T02:37:08Z
html.description.abstractDoxorubicin (1) is commonly used in the treatment of a wide range of cancers. Some N-acylhydrazones of 1 were previously found to have an improved tumour and organ selectivity. In order to clarify the molecular basis for this effect, the cellular uptake into various cancer cells and the localisation in PtK(2) potoroo kidney cells of 1 and its N-acylhydrazones derived from heptadecanoic acid (2) and 11-(menthoxycarbonyl)undecanoic acid (3) were studied drawing on their intrinsic fluorescence.


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