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dc.contributor.authorChepkirui, Clara
dc.contributor.authorRichter, Christian
dc.contributor.authorMatasyoh, Josphat Clement
dc.contributor.authorStadler, Marc
dc.date.accessioned2017-03-07T13:16:50Z
dc.date.available2017-03-07T13:16:50Z
dc.date.issued2016-12
dc.identifier.citationMonochlorinated calocerins A-D and 9-oxostrobilurin derivatives from the basidiomycete Favolaschia calocera. 2016, 132:95-101 Phytochemistryen
dc.identifier.issn1873-3700
dc.identifier.pmid27745908
dc.identifier.doi10.1016/j.phytochem.2016.10.001
dc.identifier.urihttp://hdl.handle.net/10033/620851
dc.description.abstractEight previously undescribed compounds were isolated and characterised from the supernatant and mycelium of a culture of the basidiomycete Favolaschia calocera originating from Kakamega equatorial rainforest in Kenya. These were: 9- oxostrobilurins A, G, K and I and the four monochlorinated calocerins A, B, C and D. The calocerins extend our knowledge of halogenated compounds obtained from natural sources. Four further known compounds were also identified: strobilurin G, favolon, pterulinic acid and 2,3 -dihydro-1-benzoxepin derivative. The four oxostrobilurins exhibited prominent antifungal and cytotoxic activities while the four calocerins only showed cytotoxic activity.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAntifungal Agentsen
dc.subject.meshBasidiomycotaen
dc.subject.meshBenzofuransen
dc.subject.meshDrug Screening Assays, Antitumoren
dc.subject.meshFatty Acids, Unsaturateden
dc.subject.meshHumansen
dc.subject.meshHydrocarbons, Chlorinateden
dc.subject.meshKenyaen
dc.subject.meshMethacrylatesen
dc.subject.meshMicrobial Sensitivity Testsen
dc.subject.meshOxepinsen
dc.subject.meshTriterpenesen
dc.titleMonochlorinated calocerins A-D and 9-oxostrobilurin derivatives from the basidiomycete Favolaschia calocera.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Ihoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalPhytochemistryen
refterms.dateFOA2017-12-01T00:00:00Z
html.description.abstractEight previously undescribed compounds were isolated and characterised from the supernatant and mycelium of a culture of the basidiomycete Favolaschia calocera originating from Kakamega equatorial rainforest in Kenya. These were: 9- oxostrobilurins A, G, K and I and the four monochlorinated calocerins A, B, C and D. The calocerins extend our knowledge of halogenated compounds obtained from natural sources. Four further known compounds were also identified: strobilurin G, favolon, pterulinic acid and 2,3 -dihydro-1-benzoxepin derivative. The four oxostrobilurins exhibited prominent antifungal and cytotoxic activities while the four calocerins only showed cytotoxic activity.


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