Insights into host-pathogen interactions from state-of-the-art animal models of respiratory Pseudomonas aeruginosa infections.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractPseudomonas aeruginosa is an important opportunistic pathogen that can cause acute respiratory infections in immunocompetent patients or chronic infections in immunocompromised individuals and in patients with cystic fibrosis. When acquiring the chronic infection state, bacteria are encapsulated within biofilm structures enabling them to withstand diverse environmental assaults, including immune reactions and antimicrobial therapy. Understanding the molecular interactions within the bacteria, as well as with the host or other bacteria, is essential for developing innovative treatment strategies. Such knowledge might be accumulated in vitro. However, it is ultimately necessary to confirm these findings in vivo. In the present Review, we describe state-of-the-art in vivo models that allow studying P. aeruginosa infections in molecular detail. The portrayed mammalian models exclusively focus on respiratory infections. The data obtained by alternative animal models which lack lung tissue, often provide molecular insights that are easily transferable to mammals. Importantly, these surrogate in vivo systems reveal complex molecular interactions of P. aeruginosa with the host. Herein, we also provide a critical assessment of the advantages and disadvantages of such models.
CitationInsights into host-pathogen interactions from state-of-the-art animal models of respiratory Pseudomonas aeruginosa infections. 2016, 590 (21):3941-3959 FEBS Lett.
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
- Drosophila melanogaster as an animal model for the study of Pseudomonas aeruginosa biofilm infections in vivo.
- Authors: Mulcahy H, Sibley CD, Surette MG, Lewenza S
- Issue date: 2011 Oct
- Pseudomonas aeruginosa biofilm infections: from molecular biofilm biology to new treatment possibilities.
- Authors: Tolker-Nielsen T
- Issue date: 2014 Dec
- Targeting iron uptake to control Pseudomonas aeruginosa infections in cystic fibrosis.
- Authors: Smith DJ, Lamont IL, Anderson GJ, Reid DW
- Issue date: 2013 Dec
- Effects of combined treatment with ambroxol and ciprofloxacin on catheter-associated Pseudomonas aeruginosa biofilms in a rat model.
- Authors: Lu Q, Yu J, Bao L, Ran T, Zhong H
- Issue date: 2013
- The impact of host genetic background in the Pseudomonas aeruginosa respiratory infections.
- Authors: Loré NI, Cigana C, Sipione B, Bragonzi A
- Issue date: 2018 Aug