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dc.contributor.authorNuss, Aaron M
dc.contributor.authorHeroven, Ann Kathrin
dc.contributor.authorDersch, Petra
dc.date.accessioned2017-04-03T12:11:08Z
dc.date.available2017-04-03T12:11:08Z
dc.date.issued2017-01
dc.identifier.citationRNA Regulators: Formidable Modulators of Yersinia Virulence. 2017, 25 (1):19-34 Trends Microbiol.en
dc.identifier.issn1878-4380
dc.identifier.pmid27651123
dc.identifier.doi10.1016/j.tim.2016.08.006
dc.identifier.urihttp://hdl.handle.net/10033/620878
dc.description.abstractA large repertoire of RNA-based regulatory mechanisms, including a plethora of cis- and trans-acting noncoding RNAs (ncRNAs), sensory RNA elements, regulatory RNA-binding proteins, and RNA-degrading enzymes have been uncovered lately as key players in the regulation of metabolism, stress responses, and virulence of the genus Yersinia. Many of them are strictly controlled in response to fluctuating environmental conditions sensed during the course of the infection, and certain riboregulators have already been shown to be crucial for virulence. Some of them are highly conserved among the family Enterobacteriaceae, while others are genus-, species-, or strain-specific and could contribute to the difference in Yersinia pathogenicity. Importantly, the analysis of Yersinia riboregulators has not only uncovered crucial elements and regulatory mechanisms governing host-pathogen interactions, it also revealed exciting new venues for the design of novel anti-infectives.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleRNA Regulators: Formidable Modulators of Yersinia Virulence.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalTrends in microbiologyen
refterms.dateFOA2018-01-01T00:00:00Z
html.description.abstractA large repertoire of RNA-based regulatory mechanisms, including a plethora of cis- and trans-acting noncoding RNAs (ncRNAs), sensory RNA elements, regulatory RNA-binding proteins, and RNA-degrading enzymes have been uncovered lately as key players in the regulation of metabolism, stress responses, and virulence of the genus Yersinia. Many of them are strictly controlled in response to fluctuating environmental conditions sensed during the course of the infection, and certain riboregulators have already been shown to be crucial for virulence. Some of them are highly conserved among the family Enterobacteriaceae, while others are genus-, species-, or strain-specific and could contribute to the difference in Yersinia pathogenicity. Importantly, the analysis of Yersinia riboregulators has not only uncovered crucial elements and regulatory mechanisms governing host-pathogen interactions, it also revealed exciting new venues for the design of novel anti-infectives.


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