Genetically diverse CC-founder mouse strains replicate the human influenza gene expression signature.

Elbahesh, Husni; Schughart, Klaus

dc.contributor.author	Elbahesh, Husni
dc.contributor.author	Schughart, Klaus
dc.date.accessioned	2017-05-05T07:27:21Z
dc.date.available	2017-05-05T07:27:21Z
dc.date.issued	2016-05-19
dc.identifier.citation	Genetically diverse CC-founder mouse strains replicate the human influenza gene expression signature. 2016, 6:26437 Sci Rep	en
dc.identifier.issn	2045-2322
dc.identifier.pmid	27193691
dc.identifier.doi	10.1038/srep26437
dc.identifier.uri	http://hdl.handle.net/10033/620908
dc.description.abstract	Influenza A viruses (IAV) are zoonotic pathogens that pose a major threat to human and animal health. Influenza virus disease severity is influenced by viral virulence factors as well as individual differences in host response. We analyzed gene expression changes in the blood of infected mice using a previously defined set of signature genes that was derived from changes in the blood transcriptome of IAV-infected human volunteers. We found that the human signature was reproduced well in the founder strains of the Collaborative Cross (CC) mice, thus demonstrating the relevance and importance of mouse experimental model systems for studying human influenza disease.
dc.language.iso	en	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	Genetically diverse CC-founder mouse strains replicate the human influenza gene expression signature.	en
dc.type	Article	en
dc.contributor.department	Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.	en
dc.identifier.journal	Scientific reports	en
refterms.dateFOA	2018-05-23T10:10:29Z
html.description.abstract	Influenza A viruses (IAV) are zoonotic pathogens that pose a major threat to human and animal health. Influenza virus disease severity is influenced by viral virulence factors as well as individual differences in host response. We analyzed gene expression changes in the blood of infected mice using a previously defined set of signature genes that was derived from changes in the blood transcriptome of IAV-infected human volunteers. We found that the human signature was reproduced well in the founder strains of the Collaborative Cross (CC) mice, thus demonstrating the relevance and importance of mouse experimental model systems for studying human influenza disease.