Blockade of Neutrophil's Chemokine Receptors CXCR1/2 Abrogate Liver Damage in Acute-on-Chronic Liver Failure.

Khanam, Arshi; Trehanpati, Nirupma; Riese, Peggy; Rastogi, Archana; Guzman, Carlos A.; Sarin, Shiv Kumar

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Authors

Khanam, Arshi
Trehanpati, Nirupma
Riese, Peggy

Rastogi, Archana
Guzman, Carlos A.
Sarin, Shiv Kumar

Issue Date

2017

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Abstract

Neutrophils serve as critical players in the pathogenesis of liver diseases. Chemokine receptors CXCR1 and CXCR2 are required for neutrophil chemotaxis to the site of inflammation/injury and are crucial in hepatic inflammatory response. However, key mechanism of neutrophil-mediated liver injury in acute-on-chronic liver failure (ACLF) remains highly elusive; which could be targeted for the development of new therapeutic interventions.

Citation

Blockade of Neutrophil's Chemokine Receptors CXCR1/2 Abrogate Liver Damage in Acute-on-Chronic Liver Failure. 2017, 8:464 Front Immunol

Affiliation

Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.

Type

Article

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publications of the research group vaccinology and applied microbiology (VAC)

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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/