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The myxobacterial metabolite Soraphen A inhibits HIV-1 by reducing virus production and altering virion composition.

dc.contributor.authorFleta-Soriano, Eric
dc.contributor.authorSmutná, Katarína
dc.contributor.authorMartinez, Javier P
dc.contributor.authorLorca Oró, Cristina
dc.contributor.authorSadiq, S Kashif
dc.contributor.authorMirambeau, Gilles
dc.contributor.authorLopez-Iglesias, Carmen
dc.contributor.authorBosch, Marta
dc.contributor.authorPol, Albert
dc.contributor.authorBrönstrup, Mark
dc.contributor.authorDiez, Juana
dc.contributor.authorMeyerhans, Andreas
dc.date.accessioned2017-06-14T08:39:51Z
dc.date.available2017-06-14T08:39:51Z
dc.date.issued2017-05-22
dc.identifier.citationThe myxobacterial metabolite Soraphen A inhibits HIV-1 by reducing virus production and altering virion composition. 2017 Antimicrob. Agents Chemother.en
dc.identifier.issn1098-6596
dc.identifier.pmid28533249
dc.identifier.doi10.1128/AAC.00739-17
dc.identifier.urihttp://hdl.handle.net/10033/620943
dc.description.abstractSoraphen A is a myxobacterial metabolite that blocks the acetyl-CoA carboxylase of the host, and was previously identified as a novel HIV inhibitor. Here we report that Soraphen A acts by reducing virus production and altering the gp120 virion content, impacting entry capacity and infectivity. These effects are partially reversed by addition of palmitic acid, suggesting inhibition of HIV Env palmitoylation as one of the mechanisms of antiviral action.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleThe myxobacterial metabolite Soraphen A inhibits HIV-1 by reducing virus production and altering virion composition.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre of infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalAntimicrobial agents and chemotherapyen
refterms.dateFOA2018-03-22T00:00:00Z
html.description.abstractSoraphen A is a myxobacterial metabolite that blocks the acetyl-CoA carboxylase of the host, and was previously identified as a novel HIV inhibitor. Here we report that Soraphen A acts by reducing virus production and altering the gp120 virion content, impacting entry capacity and infectivity. These effects are partially reversed by addition of palmitic acid, suggesting inhibition of HIV Env palmitoylation as one of the mechanisms of antiviral action.


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