Arvoredol: An unusual chlorinated and biofilm inhibiting polyketide from a marine  Penicillium  sp. of the Brazilian coast

Scopel, Marina; Mothes, Beatriz; Lerner, Clea B.; Henriques, Am?lia T.; Macedo, Alexandre J.; Abraham, Wolf-Rainer

dc.contributor.author	Scopel, Marina
dc.contributor.author	Mothes, Beatriz
dc.contributor.author	Lerner, Clea B.
dc.contributor.author	Henriques, Am?lia T.
dc.contributor.author	Macedo, Alexandre J.
dc.contributor.author	Abraham, Wolf-Rainer
dc.date.accessioned	2017-06-15T07:54:24Z
dc.date.available	2017-06-15T07:54:24Z
dc.date.issued	2017-06
dc.identifier.citation	Arvoredol: An unusual chlorinated and biofilm inhibiting polyketide from a marine Penicillium sp. of the Brazilian coast 2017, 20:73 Phytochemistry Letters	en
dc.identifier.issn	18743900
dc.identifier.doi	10.1016/j.phytol.2017.04.010
dc.identifier.uri	http://hdl.handle.net/10033/620946
dc.description.abstract	Penicillium sp. F37 has been isolated from the marine sponge Axinella corrugata and shown to be closely related to Penicillium maximae. From the culture of Penicillium sp. F37 arvoredol, a novel chlorinated polyketide with 6,7-dihydro-4(5H)-benzofuranone moiety has been isolated and characterized by spectroscopic methods Arvoredol prevented biofilm formation of the human pathogen Staphylococcus epidermidis at a concentration of 125 μg mL−1 by 40%. It was also active against colorectal carcinoma HCT116 cells with a MIC of 7.9 μg mL−1. © 2017 Phytochemical Society of Europe	en
dc.relation.url	http://linkinghub.elsevier.com/retrieve/pii/S1874390017300010	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	Arvoredol: An unusual chlorinated and biofilm inhibiting polyketide from a marine Penicillium sp. of the Brazilian coast
dc.type	Article	en
dc.contributor.department	Helmholtz Centre for infection research, Inhoffenstr. 7., 38124 Braunschweig, Germany.	en
dc.identifier.journal	Phytochemistry Letters	en
refterms.dateFOA	2018-07-15T00:00:00Z