Roles of Regulatory RNAs for Antibiotic Resistance in Bacteria and Their Potential Value as Novel Drug Targets.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractThe emergence of antibiotic resistance mechanisms among bacterial pathogens increases the demand for novel treatment strategies. Lately, the contribution of non-coding RNAs to antibiotic resistance and their potential value as drug targets became evident. RNA attenuator elements in mRNA leader regions couple expression of resistance genes to the presence of the cognate antibiotic. Trans-encoded small RNAs (sRNAs) modulate antibiotic tolerance by base-pairing with mRNAs encoding functions important for resistance such as metabolic enzymes, drug efflux pumps, or transport proteins. Bacteria respond with extensive changes of their sRNA repertoire to antibiotics. Each antibiotic generates a unique sRNA profile possibly causing downstream effects that may help to overcome the antibiotic challenge. In consequence, regulatory RNAs including sRNAs and their protein interaction partners such as Hfq may prove useful as targets for antimicrobial chemotherapy. Indeed, several compounds have been developed that kill bacteria by mimicking ligands for riboswitches controlling essential genes, demonstrating that regulatory RNA elements are druggable targets. Drugs acting on sRNAs are considered for combined therapies to treat infections. In this review, we address how regulatory RNAs respond to and establish resistance to antibiotics in bacteria. Approaches to target RNAs involved in intrinsic antibiotic resistance or virulence for chemotherapy will be discussed.
CitationRoles of Regulatory RNAs for Antibiotic Resistance in Bacteria and Their Potential Value as Novel Drug Targets. 2017, 8:803 Front Microbiol
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
JournalFrontiers in microbiology
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
- sRNA Target Prediction Organizing Tool (SPOT) Integrates Computational and Experimental Data To Facilitate Functional Characterization of Bacterial Small RNAs.
- Authors: King AM, Vanderpool CK, Degnan PH
- Issue date: 2019 Jan 30
- Hfq Globally Binds and Destabilizes sRNAs and mRNAs in Yersinia pestis.
- Authors: Han Y, Chen D, Yan Y, Gao X, Liu Z, Xue Y, Zhang Y, Yang R
- Issue date: 2019 Jul 16
- Systematic analysis of the role of bacterial Hfq-interacting sRNAs in the response to antibiotics.
- Authors: Kim T, Bak G, Lee J, Kim KS
- Issue date: 2015
- A Modular Genetic System for High-Throughput Profiling and Engineering of Multi-Target Small RNAs.
- Authors: Stimple SD, Lahiry A, Taris JE, Wood DW, Lease RA
- Issue date: 2018
- Riboregulation in bacteria: From general principles to novel mechanisms of the trp attenuator and its sRNA and peptide products.
- Authors: Evguenieva-Hackenberg E
- Issue date: 2021 Oct 14