Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity.

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Authors
Bankwitz, Dorothea
Doepke, Mandy
Hueging, Kathrin
Weller, Romy
Bruening, Janina
Behrendt, Patrick
Lee, Ji-Young
Vondran, Florian W R
Manns, Michael P
Bartenschlager, Ralf
Issue Date
2017-04-22

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Abstract
Hepatitis C virus (HCV) evades humoral immunity and establishes chronic infections. Virus particles circulate in complex with lipoproteins facilitating antibody escape. Apolipoprotein E (ApoE) is essential for intracellular HCV assembly and for HCV cell entry. We aimed to explore if ApoE released from non-infected cells interacts with and modulates secreted HCV particles.
Citation
Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity. 2017 J. Hepatol.
Affiliation
TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen Str.7, 30625 Hannover, Germany.
Journal
Journal of hepatology
URI
http://hdl.handle.net/10033/620981
DOI
10.1016/j.jhep.2017.04.010
PubMed ID
28438690
Type
Article
Language
en
ISSN
1600-0641
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http://creativecommons.org/licenses/by-nc-sa/4.0/
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