Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity.
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Authors
Bankwitz, DorotheaDoepke, Mandy
Hueging, Kathrin
Weller, Romy
Bruening, Janina
Behrendt, Patrick
Lee, Ji-Young
Vondran, Florian W R
Manns, Michael P
Bartenschlager, Ralf
Pietschmann, Thomas
Issue Date
2017-04-22
Metadata
Show full item recordAbstract
Hepatitis C virus (HCV) evades humoral immunity and establishes chronic infections. Virus particles circulate in complex with lipoproteins facilitating antibody escape. Apolipoprotein E (ApoE) is essential for intracellular HCV assembly and for HCV cell entry. We aimed to explore if ApoE released from non-infected cells interacts with and modulates secreted HCV particles.Citation
Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity. 2017 J. Hepatol.Affiliation
TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen Str.7, 30625 Hannover, Germany.Journal
Journal of hepatologyPubMed ID
28438690Type
ArticleLanguage
enISSN
1600-0641ae974a485f413a2113503eed53cd6c53
10.1016/j.jhep.2017.04.010
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
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