Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractPeriodontitis is an extremely prevalent disease worldwide and is driven by complex dysbiotic microbiota. Here we analyzed the transcriptional activity of the periodontal pocket microbiota from all domains of life as well as the human host in health and chronic periodontitis. Bacteria showed strong enrichment of 18 KEGG functional modules in chronic periodontitis, including bacterial chemotaxis, flagellar assembly, type III secretion system, type III CRISPR-Cas system, and two component system proteins. Upregulation of these functions was driven by the red-complex pathogens and candidate pathogens, e.g. Filifactor alocis, Prevotella intermedia, Fretibacterium fastidiosum and Selenomonas sputigena. Nine virulence factors were strongly up-regulated, among them the arginine deiminase arcA from Porphyromonas gingivalis and Mycoplasma arginini. Viruses and archaea accounted for about 0.1% and 0.22% of total putative mRNA reads, respectively, and a protozoan, Entamoeba gingivalis, was highly enriched in periodontitis. Fourteen human transcripts were enriched in periodontitis, including a gene for a ferric iron binding protein, indicating competition with the microbiota for iron, and genes associated with cancer, namely nucleolar phosphoprotein B23, ankyrin-repeat domain 30B-like protein and beta-enolase. The data provide evidence on the level of gene expression in vivo for the potentially severe impact of the dysbiotic microbiota on human health.
CitationDysbiosis in chronic periodontitis: Key microbial players and interactions with the human host. 2017, 7 (1):3703 Sci Rep
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7., 38124 Braunschweig, Germany.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
- Levels of Candidate Periodontal Pathogens in Subgingival Biofilm.
- Authors: Oliveira RR, Fermiano D, Feres M, Figueiredo LC, Teles FR, Soares GM, Faveri M
- Issue date: 2016 Jun
- Identification of Salivary Microbiota and Its Association With Host Inflammatory Mediators in Periodontitis.
- Authors: Lundmark A, Hu YOO, Huss M, Johannsen G, Andersson AF, Yucel-Lindberg T
- Issue date: 2019
- Signature of Microbial Dysbiosis in Periodontitis.
- Authors: Meuric V, Le Gall-David S, Boyer E, Acuña-Amador L, Martin B, Fong SB, Barloy-Hubler F, Bonnaure-Mallet M
- Issue date: 2017 Jul 15
- Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray.
- Authors: Colombo AP, Boches SK, Cotton SL, Goodson JM, Kent R, Haffajee AD, Socransky SS, Hasturk H, Van Dyke TE, Dewhirst F, Paster BJ
- Issue date: 2009 Sep
- Integrated metagenomic data analysis demonstrates that a loss of diversity in oral microbiota is associated with periodontitis.
- Authors: Ai D, Huang R, Wen J, Li C, Zhu J, Xia LC
- Issue date: 2017 Jan 25