Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity.
dc.contributor.author | Westendorf, Astrid M | |
dc.contributor.author | Skibbe, Kathrin | |
dc.contributor.author | Adamczyk, Alexandra | |
dc.contributor.author | Buer, Jan | |
dc.contributor.author | Geffers, Robert | |
dc.contributor.author | Hansen, Wiebke | |
dc.contributor.author | Pastille, Eva | |
dc.contributor.author | Jendrossek, Verena | |
dc.date.accessioned | 2017-07-10T12:52:15Z | |
dc.date.available | 2017-07-10T12:52:15Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity. 2017, 41 (4):1271-1284 Cell. Physiol. Biochem. | en |
dc.identifier.issn | 1421-9778 | |
dc.identifier.pmid | 28278498 | |
dc.identifier.doi | 10.1159/000464429 | |
dc.identifier.uri | http://hdl.handle.net/10033/621001 | |
dc.description.abstract | Hypoxia occurs in many pathological conditions, including inflammation and cancer. Within this context, hypoxia was shown to inhibit but also to promote T cell responses. Due to this controversial function, we aimed to explore whether an insufficient anti-tumour response during colitis-associated colon cancer could be ascribed to a hypoxic microenvironment. | |
dc.language.iso | en | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject.mesh | Animals | en |
dc.subject.mesh | Cell Differentiation | en |
dc.subject.mesh | Cell Hypoxia | en |
dc.subject.mesh | Colitis | en |
dc.subject.mesh | Colonic Neoplasms | en |
dc.subject.mesh | Hypoxia-Inducible Factor 1, alpha Subunit | en |
dc.subject.mesh | Immune Tolerance | en |
dc.subject.mesh | Immunologic Surveillance | en |
dc.subject.mesh | Interferon-gamma | en |
dc.subject.mesh | Mice | en |
dc.subject.mesh | Mice, Inbred BALB C | en |
dc.subject.mesh | Mice, Transgenic | en |
dc.subject.mesh | T-Lymphocytes, Regulatory | en |
dc.title | Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity. | en |
dc.type | Article | en |
dc.contributor.department | Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany. | en |
dc.identifier.journal | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | en |
refterms.dateFOA | 2018-06-13T19:34:56Z | |
html.description.abstract | Hypoxia occurs in many pathological conditions, including inflammation and cancer. Within this context, hypoxia was shown to inhibit but also to promote T cell responses. Due to this controversial function, we aimed to explore whether an insufficient anti-tumour response during colitis-associated colon cancer could be ascribed to a hypoxic microenvironment. |