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dc.contributor.authorWestendorf, Astrid M
dc.contributor.authorSkibbe, Kathrin
dc.contributor.authorAdamczyk, Alexandra
dc.contributor.authorBuer, Jan
dc.contributor.authorGeffers, Robert
dc.contributor.authorHansen, Wiebke
dc.contributor.authorPastille, Eva
dc.contributor.authorJendrossek, Verena
dc.date.accessioned2017-07-10T12:52:15Z
dc.date.available2017-07-10T12:52:15Z
dc.date.issued2017
dc.identifier.citationHypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity. 2017, 41 (4):1271-1284 Cell. Physiol. Biochem.en
dc.identifier.issn1421-9778
dc.identifier.pmid28278498
dc.identifier.doi10.1159/000464429
dc.identifier.urihttp://hdl.handle.net/10033/621001
dc.description.abstractHypoxia occurs in many pathological conditions, including inflammation and cancer. Within this context, hypoxia was shown to inhibit but also to promote T cell responses. Due to this controversial function, we aimed to explore whether an insufficient anti-tumour response during colitis-associated colon cancer could be ascribed to a hypoxic microenvironment.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimalsen
dc.subject.meshCell Differentiationen
dc.subject.meshCell Hypoxiaen
dc.subject.meshColitisen
dc.subject.meshColonic Neoplasmsen
dc.subject.meshHypoxia-Inducible Factor 1, alpha Subuniten
dc.subject.meshImmune Toleranceen
dc.subject.meshImmunologic Surveillanceen
dc.subject.meshInterferon-gammaen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred BALB Cen
dc.subject.meshMice, Transgenicen
dc.subject.meshT-Lymphocytes, Regulatoryen
dc.titleHypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacologyen
refterms.dateFOA2018-06-13T19:34:56Z
html.description.abstractHypoxia occurs in many pathological conditions, including inflammation and cancer. Within this context, hypoxia was shown to inhibit but also to promote T cell responses. Due to this controversial function, we aimed to explore whether an insufficient anti-tumour response during colitis-associated colon cancer could be ascribed to a hypoxic microenvironment.


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