Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

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Authors
Legrand, Nicolas
Ploss, Alexander
Balling, Rudi
Becker, Pablo D
Borsotti, Chiara
Brezillon, Nicolas
Debarry, Jennifer
de Jong, Ype
Deng, Hongkui
Di Santo, James P
Issue Date
2009-07-23

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Abstract
Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.
Citation
Humanized mice for modeling human infectious disease: challenges, progress, and outlook. 2009, 6 (1):5-9 Cell Host Microbe
Journal
Cell host & microbe
URI
http://hdl.handle.net/10033/621017
DOI
10.1016/j.chom.2009.06.006
PubMed ID
19616761
Type
Article
Language
en
ISSN
1934-6069
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  • Creative Commons
http://creativecommons.org/licenses/by-nc-sa/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/