Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis.
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Authors
Helaly, Soleiman E
Kuephadungphan, Wilawan
Phongpaichit, Souwalak
Luangsa-Ard, Janet Jennifer
Rukachaisirikul, Vatcharin
Stadler, Marc

Issue Date
2017-06-14
Metadata
Show full item recordAbstract
Five new compounds including the glycosylated β-naphthol (1, akanthol), a glycosylated pyrazine (2, akanthozine), and three amide derivatives including a hydroxamic acid derivative (3-5) were isolated from the spider-associated fungus Akanthomyces novoguineensis (Cordycipitaceae, Ascomycota). Their structures were elucidated by using high resolution mass spectrometry (HRMS) and NMR spectroscopy. In this study, the antimicrobial, cytotoxic, anti-biofilm, and nematicidal activities of the new compounds were evaluated. The distribution pattern of secondary metabolites in the species was also revealed in which more isolates of A. novoguineensis were encountered and their secondary metabolite profiles were examined using analytical HPLC with diode array and mass spectrometric detection (HPLC-DAD/MS). Remarkably, all isolated compounds are specifically produced by A. novoguineensis.Citation
Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis. 2017, 22 (6) MoleculesAffiliation
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.Journal
Molecules (Basel, Switzerland)PubMed ID
28613244Type
ArticleLanguage
enISSN
1420-3049ae974a485f413a2113503eed53cd6c53
10.3390/molecules22060991
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
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