HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsRaza, Syed Ahsan
Demiray, Yunus Emre
MetadataShow full item record
AbstractCholinergic neuromodulation in the hippocampus controls the salience of background context memory acquired in the presence of elemental stimuli predicting an aversive reinforcement. With pharmacogenetic inhibition we here demonstrate that hilar perforant path-associated (HIPP) cells of the dentate gyrus mediate the devaluation of background context memory during Pavlovian fear conditioning. The salience adjustment is sensitive to reduction of hilar neuropeptide Y (NPY) expression via dominant negative CREB expression in HIPP cells and to acute blockage of NPY-Y1 receptors in the dentate gyrus during conditioning. We show that NPY transmission and HIPP cell activity contribute to inhibitory effects of acetylcholine in the dentate gyrus and that M1 muscarinic receptors mediate the cholinergic activation of HIPP cells as well as their control of background context salience. Our data provide evidence for a peptidergic local circuit in the dentate gyrus that mediates the cholinergic encoding of background context salience during fear memory acquisition.Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST(+) interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY(+) hilar perforant path associated interneurons and NPY signaling in the dentate gyrus.
CitationHIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. 2017, 8 (1):189 Nat Commun
AffiliationHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
- Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus.
- Authors: Hattiangady B, Rao MS, Shetty GA, Shetty AK
- Issue date: 2005 Oct
- Neuropeptide Y in the dentate gyrus.
- Authors: Sperk G, Hamilton T, Colmers WF
- Issue date: 2007
- Tuning afferent synapses of hippocampal interneurons by neuropeptide Y.
- Authors: Ledri M, Sørensen AT, Erdelyi F, Szabo G, Kokaia M
- Issue date: 2011 Feb
- Beta-estradiol increases dentate gyrus inhibition in female rats via augmentation of hilar neuropeptide Y.
- Authors: Velísková J, Velísek L
- Issue date: 2007 May 30
- Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus.
- Authors: Howell OW, Doyle K, Goodman JH, Scharfman HE, Herzog H, Pringle A, Beck-Sickinger AG, Gray WP
- Issue date: 2005 May