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dc.contributor.authorRaza, Syed Ahsan
dc.contributor.authorAlbrecht, Anne
dc.contributor.authorÇalışkan, Gürsel
dc.contributor.authorMüller, Bettina
dc.contributor.authorDemiray, Yunus Emre
dc.contributor.authorLudewig, Susann
dc.contributor.authorMeis, Susanne
dc.contributor.authorFaber, Nicolai
dc.contributor.authorHartig, Roland
dc.contributor.authorSchraven, Burkhart
dc.contributor.authorLessmann, Volkmar
dc.contributor.authorSchwegler, Herbert
dc.contributor.authorStork, Oliver
dc.date.accessioned2017-08-17T13:26:03Z
dc.date.available2017-08-17T13:26:03Z
dc.date.issued2017-08-04
dc.identifier.citationHIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. 2017, 8 (1):189 Nat Communen
dc.identifier.issn2041-1723
dc.identifier.pmid28775269
dc.identifier.doi10.1038/s41467-017-00205-3
dc.identifier.urihttp://hdl.handle.net/10033/621064
dc.description.abstractCholinergic neuromodulation in the hippocampus controls the salience of background context memory acquired in the presence of elemental stimuli predicting an aversive reinforcement. With pharmacogenetic inhibition we here demonstrate that hilar perforant path-associated (HIPP) cells of the dentate gyrus mediate the devaluation of background context memory during Pavlovian fear conditioning. The salience adjustment is sensitive to reduction of hilar neuropeptide Y (NPY) expression via dominant negative CREB expression in HIPP cells and to acute blockage of NPY-Y1 receptors in the dentate gyrus during conditioning. We show that NPY transmission and HIPP cell activity contribute to inhibitory effects of acetylcholine in the dentate gyrus and that M1 muscarinic receptors mediate the cholinergic activation of HIPP cells as well as their control of background context salience. Our data provide evidence for a peptidergic local circuit in the dentate gyrus that mediates the cholinergic encoding of background context salience during fear memory acquisition.Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST(+) interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY(+) hilar perforant path associated interneurons and NPY signaling in the dentate gyrus.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleHIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalNature communicationsen
refterms.dateFOA2018-06-13T01:08:41Z
html.description.abstractCholinergic neuromodulation in the hippocampus controls the salience of background context memory acquired in the presence of elemental stimuli predicting an aversive reinforcement. With pharmacogenetic inhibition we here demonstrate that hilar perforant path-associated (HIPP) cells of the dentate gyrus mediate the devaluation of background context memory during Pavlovian fear conditioning. The salience adjustment is sensitive to reduction of hilar neuropeptide Y (NPY) expression via dominant negative CREB expression in HIPP cells and to acute blockage of NPY-Y1 receptors in the dentate gyrus during conditioning. We show that NPY transmission and HIPP cell activity contribute to inhibitory effects of acetylcholine in the dentate gyrus and that M1 muscarinic receptors mediate the cholinergic activation of HIPP cells as well as their control of background context salience. Our data provide evidence for a peptidergic local circuit in the dentate gyrus that mediates the cholinergic encoding of background context salience during fear memory acquisition.Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST(+) interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY(+) hilar perforant path associated interneurons and NPY signaling in the dentate gyrus.


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