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dc.contributor.authorPfaender, Stephanie
dc.contributor.authorWalter, Stephanie
dc.contributor.authorTodt, Daniel
dc.contributor.authorBehrendt, Patrick
dc.contributor.authorDoerrbecker, Juliane
dc.contributor.authorWölk, Benno
dc.contributor.authorEngelmann, Michael
dc.contributor.authorGravemann, Ute
dc.contributor.authorSeltsam, Axel
dc.contributor.authorSteinmann, Joerg
dc.contributor.authorBurbelo, Peter D
dc.contributor.authorKlawonn, Frank
dc.contributor.authorFeige, Karsten
dc.contributor.authorPietschmann, Thomas
dc.contributor.authorCavalleri, Jessika-M V
dc.contributor.authorSteinmann, Eike
dc.date.accessioned2017-08-29T08:45:06Z
dc.date.available2017-08-29T08:45:06Z
dc.date.issued2015-09
dc.identifier.citationAssessment of cross-species transmission of hepatitis C virus-related non-primate hepacivirus in a population of humans at high risk of exposure. 2015, 96 (9):2636-42 J. Gen. Virol.en
dc.identifier.issn1465-2099
dc.identifier.pmid26041875
dc.identifier.doi10.1099/vir.0.000208
dc.identifier.urihttp://hdl.handle.net/10033/621077
dc.description.abstractThe recent discovery of hepatitis C virus (HCV)-related viruses in different animal species has raised new speculations regarding the origin of HCV and the possibility of a zoonotic source responsible for the endemic HCV transmission. As a consequence, these new findings prompt questions regarding the potential for cross-species transmissions of hepaciviruses. The closest relatives to HCV discovered to date are the non-primate hepaciviruses (NPHVs), which have been described to infect horses. To evaluate the risk of a potential zoonotic transmission, we analysed NPHV RNA and antibodies in humans with occupational exposure to horses in comparison with a low-risk group. Both groups were negative for NPHV RNA, even though low seroreactivities against various NPHV antigens could be detected irrespective of the group. In conclusion, we did not observe evidence of NPHV transmission between horses and humans.
dc.language.isoenen
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/281473en
dc.rightsopenAccessen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAdulten
dc.subject.meshAgricultural Workers' Diseasesen
dc.subject.meshAnimalsen
dc.subject.meshFemaleen
dc.subject.meshHepacivirusen
dc.subject.meshHepatitis Cen
dc.subject.meshHorse Diseasesen
dc.subject.meshHorsesen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshOccupational Exposureen
dc.subject.meshPhylogenyen
dc.subject.meshZoonosesen
dc.titleAssessment of cross-species transmission of hepatitis C virus-related non-primate hepacivirus in a population of humans at high risk of exposure.en
dc.typeArticleen
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.en
dc.identifier.journalThe Journal of general virologyen
refterms.dateFOA2018-06-12T22:01:42Z
html.description.abstractThe recent discovery of hepatitis C virus (HCV)-related viruses in different animal species has raised new speculations regarding the origin of HCV and the possibility of a zoonotic source responsible for the endemic HCV transmission. As a consequence, these new findings prompt questions regarding the potential for cross-species transmissions of hepaciviruses. The closest relatives to HCV discovered to date are the non-primate hepaciviruses (NPHVs), which have been described to infect horses. To evaluate the risk of a potential zoonotic transmission, we analysed NPHV RNA and antibodies in humans with occupational exposure to horses in comparison with a low-risk group. Both groups were negative for NPHV RNA, even though low seroreactivities against various NPHV antigens could be detected irrespective of the group. In conclusion, we did not observe evidence of NPHV transmission between horses and humans.


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