Increased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells.
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Authors
Ribeiro, Giovanni MonteiroMatsumoto, Cristianne Kayoko
Real, Fernando
Teixeira, Daniela
Duarte, Rafael Silva
Mortara, Renato Arruda
Leão, Sylvia Cardoso
de Souza Carvalho-Wodarz, Cristiane
Issue Date
2017-09-13
Metadata
Show full item recordAbstract
Outbreaks of infections caused by rapidly growing mycobacteria have been reported worldwide generally associated with medical procedures. Mycobacterium abscessus subsp. massiliense CRM0019 was obtained during an epidemic of postsurgical infections and was characterized by increased persistence in vivo. To better understand the successful survival strategies of this microorganism, we evaluated its infectivity and proliferation in macrophages (RAW and BMDM) and alveolar epithelial cells (A549). For that, we assessed the following parameters, for both M. abscessus CRM0019 as well as the reference strain M. abscessus ATCC 19977: internalization, intracellular survival for up 3 days, competence to subvert lysosome fusion and the intracellular survival after cell reinfection.Citation
Increased survival and proliferation of the epidemic strain Mycobacterium abscessus subsp. massiliense CRM0019 in alveolar epithelial cells. 2017, 17 (1):195 BMC Microbiol.Affiliation
Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Universitycampus E8.1, 66123 Saarbrücken, Germany.Journal
BMC microbiologyPubMed ID
28903728Type
ArticleLanguage
enISSN
1471-2180ae974a485f413a2113503eed53cd6c53
10.1186/s12866-017-1102-7
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
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