Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.

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Authors
Prajeeth, Chittappen K
Kronisch, Julius
Khorooshi, Reza
Knier, Benjamin
Toft-Hansen, Henrik
Gudi, Viktoria
Floess, Stefan
Huehn, Jochen
Owens, Trevor
Korn, Thomas
Issue Date
2017-10-16

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Abstract
Autoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in the central nervous system (CNS). Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of the neuroinflammation. Previously, we have shown that only Th1 but not Th17 effectors activate microglia. However, it is not clear which cells are targets of Th17 effectors in the CNS.
Citation
Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties. 2017, 14 (1):204 J Neuroinflammation
Affiliation
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Journal
Journal of neuroinflammation
URI
http://hdl.handle.net/10033/621161
DOI
10.1186/s12974-017-0978-3
PubMed ID
29037246
Type
Article
Language
en
ISSN
1742-2094
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http://creativecommons.org/licenses/by-nc-sa/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/