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Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.

dc.contributor.authorPrajeeth, Chittappen K
dc.contributor.authorKronisch, Julius
dc.contributor.authorKhorooshi, Reza
dc.contributor.authorKnier, Benjamin
dc.contributor.authorToft-Hansen, Henrik
dc.contributor.authorGudi, Viktoria
dc.contributor.authorFloess, Stefan
dc.contributor.authorHuehn, Jochen
dc.contributor.authorOwens, Trevor
dc.contributor.authorKorn, Thomas
dc.contributor.authorStangel, Martin
dc.date.accessioned2017-11-06T14:31:09Z
dc.date.available2017-11-06T14:31:09Z
dc.date.issued2017-10-16
dc.identifier.citationEffectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties. 2017, 14 (1):204 J Neuroinflammationen
dc.identifier.issn1742-2094
dc.identifier.pmid29037246
dc.identifier.doi10.1186/s12974-017-0978-3
dc.identifier.urihttp://hdl.handle.net/10033/621161
dc.description.abstractAutoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in the central nervous system (CNS). Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of the neuroinflammation. Previously, we have shown that only Th1 but not Th17 effectors activate microglia. However, it is not clear which cells are targets of Th17 effectors in the CNS.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleEffectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalJournal of neuroinflammationen
refterms.dateFOA2018-06-13T02:42:45Z
html.description.abstractAutoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in the central nervous system (CNS). Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of the neuroinflammation. Previously, we have shown that only Th1 but not Th17 effectors activate microglia. However, it is not clear which cells are targets of Th17 effectors in the CNS.


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