Redispersible spray-dried lipid-core nanocapsules intended for oral delivery: the influence of the particle number on redispersibility.
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Authors
Andrade, Diego Fontana deVukosavljevic, Branko
Benvenutti, Edilson Valmir
Pohlmann, Adriana Raffin
Guterres, Sílvia Stanisçuaski
Windbergs, Maike
Beck, Ruy Carlos Ruver
Issue Date
2017-11-20
Metadata
Show full item recordAbstract
This study proposes a new approach to produce easily redispersible spray-dried lipid-core nanocapsules (LNC) intended for oral administration, evaluating the influence of the particle number density of the fed sample. The proposed approach to develop redispersible spray-dried LNC formulations intended for oral route is innovative, evidencing the needing of an optimization of the initial particle number density in the liquid suspension of nanocapsules. A mixture of maltodextrin and L-leucine (90:10 w/w) was used as drying adjuvant. Dynamic light scattering, turbidimetry, determination of surface area and pore size distribution, electron microscopy and confocal Raman microscopy (CRM) were used to characterize the proposed system and to better understand the differences in the redispersion behavior. An easily aqueous redispersion of the spray-dried powder composed of maltodextrin and L-leucine (90:10 w/w) was obtained, depending on the particle number density. Their surface area decreased in the presence of LNC. CRM enabled the visualization of the spatial distribution of the different compounds in the powders affording to better understand the influence of the particle number density of the fed sample on their redispersion behavior. This study shows the need for optimizing initial particle number density in the liquid formulation to develop redispersible spray-dried LNC powders.Citation
Redispersible spray-dried lipid-core nanocapsules intended for oral delivery: the influence of the particle number on redispersibility. 2017:1-12 Pharm Dev TechnolAffiliation
Helmholtz-Institut für pharmazeitische Forschung Saarland, Universitäzscampus E8.1, 66123 Saarbrücken, Germany.PubMed ID
29095657Type
ArticleLanguage
enISSN
1097-9867ae974a485f413a2113503eed53cd6c53
10.1080/10837450.2017.1400559
Scopus Count
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- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
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