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dc.contributor.authorHe, Jin-Shu
dc.contributor.authorMeyer-Hermann, Michael
dc.contributor.authorXiangying, Deng
dc.contributor.authorZuan, Lim Yok
dc.contributor.authorJones, Leigh Ann
dc.contributor.authorRamakrishna, Lakshmi
dc.contributor.authorde Vries, Victor C
dc.contributor.authorDolpady, Jayashree
dc.contributor.authorAina, Hoi
dc.contributor.authorJoseph, Sabrina
dc.contributor.authorNarayanan, Sriram
dc.contributor.authorSubramaniam, Sharrada
dc.contributor.authorPuthia, Manoj
dc.contributor.authorWong, Glenn
dc.contributor.authorXiong, Huizhong
dc.contributor.authorPoidinger, Michael
dc.contributor.authorUrban, Joseph F
dc.contributor.authorLafaille, Juan J
dc.contributor.authorCurotto de Lafaille, Maria A
dc.date.accessioned2017-12-05T13:23:11Z
dc.date.available2017-12-05T13:23:11Z
dc.date.issued2013-11-18
dc.identifier.citationThe distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. 2013, 210 (12):2755-71 J. Exp. Med.en
dc.identifier.issn1540-9538
dc.identifier.pmid24218137
dc.identifier.doi10.1084/jem.20131539
dc.identifier.urihttp://hdl.handle.net/10033/621196
dc.description.abstractThe mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE(+) cells in memory responses is particularly unclear. IgE(+) B cell differentiation is characterized by a transient GC phase, a bias toward the plasma cell (PC) fate, and dependence on sequential switching for the production of high-affinity IgE. We show here that IgE(+) GC B cells are unfit to undergo the conventional GC differentiation program due to impaired B cell receptor function and increased apoptosis. IgE(+) GC cells fail to populate the GC light zone and are unable to contribute to the memory and long-lived PC compartments. Furthermore, we demonstrate that direct and sequential switching are linked to distinct B cell differentiation fates: direct switching generates IgE(+) GC cells, whereas sequential switching gives rise to IgE(+) PCs. We propose a comprehensive model for the generation and memory of IgE responses.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimalsen
dc.subject.meshApoptosisen
dc.subject.meshB-Lymphocytesen
dc.subject.meshCell Differentiationen
dc.subject.meshGerminal Centeren
dc.subject.meshGreen Fluorescent Proteinsen
dc.subject.meshImmunoglobulin Class Switchingen
dc.subject.meshImmunoglobulin Een
dc.subject.meshImmunoglobulin Gen
dc.subject.meshImmunologic Memoryen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred BALB Cen
dc.subject.meshMice, Transgenicen
dc.subject.meshModels, Immunologicalen
dc.subject.meshNippostrongylusen
dc.subject.meshPlasma Cellsen
dc.subject.meshReceptors, Antigen, B-Cellen
dc.subject.meshSignal Transductionen
dc.subject.meshStrongylida Infectionsen
dc.titleThe distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response.en
dc.typeArticleen
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen-Str.7, 30625 Hannover, Germany.en
dc.identifier.journalThe Journal of experimental medicineen
refterms.dateFOA2018-06-13T15:48:22Z
html.description.abstractThe mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE(+) cells in memory responses is particularly unclear. IgE(+) B cell differentiation is characterized by a transient GC phase, a bias toward the plasma cell (PC) fate, and dependence on sequential switching for the production of high-affinity IgE. We show here that IgE(+) GC B cells are unfit to undergo the conventional GC differentiation program due to impaired B cell receptor function and increased apoptosis. IgE(+) GC cells fail to populate the GC light zone and are unable to contribute to the memory and long-lived PC compartments. Furthermore, we demonstrate that direct and sequential switching are linked to distinct B cell differentiation fates: direct switching generates IgE(+) GC cells, whereas sequential switching gives rise to IgE(+) PCs. We propose a comprehensive model for the generation and memory of IgE responses.


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