Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells.

Geis, Franziska K; Galla, Melanie; Hoffmann, Dirk; Kuehle, Johannes; Zychlinski, Daniela; Maetzig, Tobias; Schott, Juliane W; Schwarzer, Adrian; Goffinet, Christine; Goff, Stephen P; Schambach, Axel

dc.contributor.author	Geis, Franziska K
dc.contributor.author	Galla, Melanie
dc.contributor.author	Hoffmann, Dirk
dc.contributor.author	Kuehle, Johannes
dc.contributor.author	Zychlinski, Daniela
dc.contributor.author	Maetzig, Tobias
dc.contributor.author	Schott, Juliane W
dc.contributor.author	Schwarzer, Adrian
dc.contributor.author	Goffinet, Christine
dc.contributor.author	Goff, Stephen P
dc.contributor.author	Schambach, Axel
dc.date.accessioned	2017-12-13T15:14:28Z
dc.date.available	2017-12-13T15:14:28Z
dc.date.issued	2017-05-31
dc.identifier.citation	Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells. 2017, 14 (1):34 Retrovirology	en
dc.identifier.issn	1742-4690
dc.identifier.pmid	28569216
dc.identifier.doi	10.1186/s12977-017-0358-1
dc.identifier.uri	http://hdl.handle.net/10033/621206
dc.description.abstract	Retroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in gene and cell therapy. However, numerous cell types are resistant or less permissive to retrovirus infection due to the presence of active defense mechanisms, or the absence of important cellular host co-factors. In contrast to multipotent stem cells, pluripotent stem cells (PSC) have potential to differentiate into all three germ layers. Much remains to be elucidated in the field of anti-viral immunity in stem cells, especially in PSC.
dc.language.iso	en	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells.	en
dc.type	Article	en
dc.contributor.department	TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.	en
dc.identifier.journal	Retrovirology	en
refterms.dateFOA	2018-06-12T17:18:06Z
html.description.abstract	Retroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in gene and cell therapy. However, numerous cell types are resistant or less permissive to retrovirus infection due to the presence of active defense mechanisms, or the absence of important cellular host co-factors. In contrast to multipotent stem cells, pluripotent stem cells (PSC) have potential to differentiate into all three germ layers. Much remains to be elucidated in the field of anti-viral immunity in stem cells, especially in PSC.