Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging.
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Authors
Wagner, StefanieHauck, Dirk
Hoffmann, Michael
Sommer, Roman
Joachim, Ines
Müller, Rolf

Imberty, Anne
Varrot, Annabelle
Titz, Alexander

Issue Date
2017-09-28
Metadata
Show full item recordAbstract
Biofilm formation by pathogenic bacteria is a hallmark of chronic infections. In many cases, lectins play key roles in establishing biofilms. The pathogen Pseudomonas aeruginosa often exhibiting various drug resistances employs its lectins LecA and LecB as virulence factors and biofilm building blocks. Therefore, inhibition of the function of these proteins is thought to have potential in developing "pathoblockers" preventing biofilm formation and virulence. A covalent lectin inhibitor specific to a carbohydrate binding site is described for the first time. Its application in the LecA-specific in vitro imaging of biofilms formed by P. aeruginosa is also reported.Citation
Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging. 2017 Angew. Chem. Int. Ed. Engl.Affiliation
HIPS, Helmholtz-Institut für pharmazeutische Forchung Saarland, Universitätscampus E8.1, 66123 Saarbrücken, Germany.PubMed ID
28960731Type
ArticleLanguage
enISSN
1521-3773ae974a485f413a2113503eed53cd6c53
10.1002/anie.201709368
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
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