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dc.contributor.authorWagner, Stefanie
dc.contributor.authorHauck, Dirk
dc.contributor.authorHoffmann, Michael
dc.contributor.authorSommer, Roman
dc.contributor.authorJoachim, Ines
dc.contributor.authorMüller, Rolf
dc.contributor.authorImberty, Anne
dc.contributor.authorVarrot, Annabelle
dc.contributor.authorTitz, Alexander
dc.date.accessioned2017-12-20T10:44:14Z
dc.date.available2017-12-20T10:44:14Z
dc.date.issued2017-09-28
dc.identifier.citationCovalent Lectin Inhibition and Application in Bacterial Biofilm Imaging. 2017 Angew. Chem. Int. Ed. Engl.en
dc.identifier.issn1521-3773
dc.identifier.pmid28960731
dc.identifier.doi10.1002/anie.201709368
dc.identifier.urihttp://hdl.handle.net/10033/621212
dc.description.abstractBiofilm formation by pathogenic bacteria is a hallmark of chronic infections. In many cases, lectins play key roles in establishing biofilms. The pathogen Pseudomonas aeruginosa often exhibiting various drug resistances employs its lectins LecA and LecB as virulence factors and biofilm building blocks. Therefore, inhibition of the function of these proteins is thought to have potential in developing "pathoblockers" preventing biofilm formation and virulence. A covalent lectin inhibitor specific to a carbohydrate binding site is described for the first time. Its application in the LecA-specific in vitro imaging of biofilms formed by P. aeruginosa is also reported.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleCovalent Lectin Inhibition and Application in Bacterial Biofilm Imaging.en
dc.typeArticleen
dc.contributor.departmentHIPS, Helmholtz-Institut für pharmazeutische Forchung Saarland, Universitätscampus E8.1, 66123 Saarbrücken, Germany.en
dc.identifier.journalAngewandte Chemie (International ed. in English)en
html.description.abstractBiofilm formation by pathogenic bacteria is a hallmark of chronic infections. In many cases, lectins play key roles in establishing biofilms. The pathogen Pseudomonas aeruginosa often exhibiting various drug resistances employs its lectins LecA and LecB as virulence factors and biofilm building blocks. Therefore, inhibition of the function of these proteins is thought to have potential in developing "pathoblockers" preventing biofilm formation and virulence. A covalent lectin inhibitor specific to a carbohydrate binding site is described for the first time. Its application in the LecA-specific in vitro imaging of biofilms formed by P. aeruginosa is also reported.


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