The biology and mathematical modelling of glioma invasion: a review.

Alfonso, J C L; Talkenberger, K; Seifert, M; Klink, B; Hawkins-Daarud, A; Swanson, K R; Hatzikirou, H; Deutsch, A

dc.contributor.author	Alfonso, J C L
dc.contributor.author	Talkenberger, K
dc.contributor.author	Seifert, M
dc.contributor.author	Klink, B
dc.contributor.author	Hawkins-Daarud, A
dc.contributor.author	Swanson, K R
dc.contributor.author	Hatzikirou, H
dc.contributor.author	Deutsch, A
dc.date.accessioned	2018-01-09T11:59:13Z
dc.date.available	2018-01-09T11:59:13Z
dc.date.issued	2017-11
dc.identifier.citation	The biology and mathematical modelling of glioma invasion: a review. 2017, 14 (136) J R Soc Interface	en
dc.identifier.issn	1742-5662
dc.identifier.pmid	29118112
dc.identifier.doi	10.1098/rsif.2017.0490
dc.identifier.uri	http://hdl.handle.net/10033/621227
dc.description.abstract	Adult gliomas are aggressive brain tumours associated with low patient survival rates and limited life expectancy. The most important hallmark of this type of tumour is its invasive behaviour, characterized by a markedly phenotypic plasticity, infiltrative tumour morphologies and the ability of malignant progression from low- to high-grade tumour types. Indeed, the widespread infiltration of healthy brain tissue by glioma cells is largely responsible for poor prognosis and the difficulty of finding curative therapies. Meanwhile, mathematical models have been established to analyse potential mechanisms of glioma invasion. In this review, we start with a brief introduction to current biological knowledge about glioma invasion, and then critically review and highlight future challenges for mathematical models of glioma invasion.
dc.language.iso	en	en
dc.relation.url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721156/	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	The biology and mathematical modelling of glioma invasion: a review.	en
dc.type	Article	en
dc.contributor.department	BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56, 38106 Braunschweig, Germany.	en
dc.identifier.journal	Journal of the Royal Society, Interface	en
dc.identifier.pmcid	5721156
refterms.dateFOA	2018-06-13T04:12:07Z
html.description.abstract	Adult gliomas are aggressive brain tumours associated with low patient survival rates and limited life expectancy. The most important hallmark of this type of tumour is its invasive behaviour, characterized by a markedly phenotypic plasticity, infiltrative tumour morphologies and the ability of malignant progression from low- to high-grade tumour types. Indeed, the widespread infiltration of healthy brain tissue by glioma cells is largely responsible for poor prognosis and the difficulty of finding curative therapies. Meanwhile, mathematical models have been established to analyse potential mechanisms of glioma invasion. In this review, we start with a brief introduction to current biological knowledge about glioma invasion, and then critically review and highlight future challenges for mathematical models of glioma invasion.