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dc.contributor.authorTata, Muralidhar
dc.contributor.authorAmman, Fabian
dc.contributor.authorPawar, Vinay
dc.contributor.authorWolfinger, Michael T
dc.contributor.authorWeiss, Siegfried
dc.contributor.authorHäussler, Susanne
dc.contributor.authorBläsi, Udo
dc.date.accessioned2018-01-23T14:51:07Z
dc.date.available2018-01-23T14:51:07Z
dc.date.issued2017
dc.identifier.citationThe Anaerobically Induced sRNA PaiI Affects Denitrification in Pseudomonas aeruginosa PA14. 2017, 8:2312 Front Microbiolen
dc.identifier.issn1664-302X
dc.identifier.pmid29218039
dc.identifier.doi10.3389/fmicb.2017.02312
dc.identifier.urihttp://hdl.handle.net/10033/621251
dc.description.abstractPseudomonas aeruginosa is an opportunistic pathogen that can thrive by anaerobic respiration in the lungs of cystic fibrosis patients using nitrate as terminal electron acceptor. Here, we report the identification and characterization of the small RNA PaiI in the P. aeruginosa strain 14 (PA14). PaiI is anaerobically induced in the presence of nitrate and depends on the two-component system NarXL. Our studies revealed that PaiI is required for efficient denitrification affecting the conversion of nitrite to nitric oxide. In the absence of PaiI anaerobic growth was impaired on glucose, which can be reconciled with a decreased uptake of the carbon source under these conditions. The importance of PaiI for anaerobic growth is further underlined by the observation that a paiI deletion mutant was impaired in growth in murine tumors.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleThe Anaerobically Induced sRNA PaiI Affects Denitrification in Pseudomonas aeruginosa PA14.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalFrontiers in microbiologyen
refterms.dateFOA2018-06-13T19:33:30Z
html.description.abstractPseudomonas aeruginosa is an opportunistic pathogen that can thrive by anaerobic respiration in the lungs of cystic fibrosis patients using nitrate as terminal electron acceptor. Here, we report the identification and characterization of the small RNA PaiI in the P. aeruginosa strain 14 (PA14). PaiI is anaerobically induced in the presence of nitrate and depends on the two-component system NarXL. Our studies revealed that PaiI is required for efficient denitrification affecting the conversion of nitrite to nitric oxide. In the absence of PaiI anaerobic growth was impaired on glucose, which can be reconciled with a decreased uptake of the carbon source under these conditions. The importance of PaiI for anaerobic growth is further underlined by the observation that a paiI deletion mutant was impaired in growth in murine tumors.


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