Bioactive Compounds Produced by Hypoxylon fragiforme against Staphylococcus aureus Biofilms.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsYuyama, Kamila Tomoko
MetadataShow full item record
AbstractTreating infections organized in biofilms is a challenge due to the resistance of the pathogens against antibiotics and host immune cells. Many fungi grow in a wet environment, favorable for the growth of bacterial biofilms, and we speculated that fungi possess some strategies to control these bacterial biofilms. A fungus identified as Hypoxylon fragiforme, was collected in the Harz Mountains, Germany, and its mycelial culture was fermented in different culture media for 67 days to test its biological potential against bacterial biofilms. Sclerin, sclerin diacid and its 3-methyl monoester (methyl 1-(5-hydroxy-6-carboxylic-2,3,4-trimethylphenyl) propionate) are here described for the first time from this fungus. Sclerin and its diacid interfered with the biofilm formation of the pathogen Staphylococcus aureus, inhibiting 86% and 80% of the biofilm at 256 μg mL-1, respectively, but not killing the bacterium. Interestingly, the monomethylester of sclerin diacid was inactive. Although these compounds did not possess any activity against a pre-formed biofilm, they prevented its formation at subtoxic concentrations. Furthermore, sclerin and its diacid displayed a high specificity against Staphylococcus aureus, indicating a good strategy against pathogenic biofilms when combined with antibiotics.
CitationBioactive Compounds Produced by Hypoxylon fragiforme against Staphylococcus aureus Biofilms. 2017, 5 (4) Microorganisms
AffiliationHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
- Unsaturated Fatty Acids Control Biofilm Formation of Staphylococcus aureus and Other Gram-Positive Bacteria.
- Authors: Yuyama KT, Rohde M, Molinari G, Stadler M, Abraham WR
- Issue date: 2020 Nov 8
- Cytochalasans Act as Inhibitors of Biofilm Formation of Staphylococcus Aureus.
- Authors: Yuyama KT, Wendt L, Surup F, Kretz R, Chepkirui C, Wittstein K, Boonlarppradab C, Wongkanoun S, Luangsa-Ard J, Stadler M, Abraham WR
- Issue date: 2018 Oct 30
- Aurantiogliocladin inhibits biofilm formation at subtoxic concentrations.
- Authors: Yuyama KT, Neves TSPDC, Memória MT, Tartuci IT, Abraham WR
- Issue date: 2017
- Antibacterial Effects of Phage Lysin LysGH15 on Planktonic Cells and Biofilms of Diverse Staphylococci.
- Authors: Zhang Y, Cheng M, Zhang H, Dai J, Guo Z, Li X, Ji Y, Cai R, Xi H, Wang X, Xue Y, Sun C, Feng X, Lei L, Han W, Gu J
- Issue date: 2018 Aug 1
- Commensal Protection of Staphylococcus aureus against Antimicrobials by Candida albicans Biofilm Matrix.
- Authors: Kong EF, Tsui C, Kucharíková S, Andes D, Van Dijck P, Jabra-Rizk MA
- Issue date: 2016 Oct 11