Show simple item record

dc.contributor.authorChepkirui, Clara
dc.contributor.authorSum, Winnie C
dc.contributor.authorCheng, Tian
dc.contributor.authorMatasyoh, Josphat C
dc.contributor.authorDecock, Cony
dc.contributor.authorStadler, Marc
dc.date.accessioned2018-02-20T15:16:34Z
dc.date.available2018-02-20T15:16:34Z
dc.date.issued2018-02-09
dc.identifier.citationAethiopinolones A-E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica. 2018, 23 (2) Moleculesen
dc.identifier.issn1420-3049
dc.identifier.pmid29425150
dc.identifier.doi10.3390/molecules23020369
dc.identifier.urihttp://hdl.handle.net/10033/621288
dc.description.abstractA mycelial culture of the Kenyan basidiomyceteFomitiporia aethiopicawas fermented on rice and the cultures were extracted with methanol. Subsequent HPLC profiling and preparative chromatography of its crude extract led to the isolation of five previously undescribed pregnenolone type triterpenes1-5, for which we propose the trivial name aethiopinolones A-E. The chemical structures of the aethiopinolones were determined by extensive 1D- and 2D-NMR, and HRMS data analysis. The compounds exhibited moderate cytotoxic effects against various human cancer cell lines, but they were found devoid of significant nematicidal and antimicrobial activities.
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleAethiopinolones A-E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalMolecules (Basel, Switzerland)en
refterms.dateFOA2018-06-12T21:24:21Z
html.description.abstractA mycelial culture of the Kenyan basidiomyceteFomitiporia aethiopicawas fermented on rice and the cultures were extracted with methanol. Subsequent HPLC profiling and preparative chromatography of its crude extract led to the isolation of five previously undescribed pregnenolone type triterpenes1-5, for which we propose the trivial name aethiopinolones A-E. The chemical structures of the aethiopinolones were determined by extensive 1D- and 2D-NMR, and HRMS data analysis. The compounds exhibited moderate cytotoxic effects against various human cancer cell lines, but they were found devoid of significant nematicidal and antimicrobial activities.


Files in this item

Thumbnail
Name:
Chepkirui et al.pdf
Size:
714.0Kb
Format:
PDF
Description:
Open Access publication

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by-nc-sa/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/