Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria.
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Authors
Hoffmann, ThomasKrug, Daniel
Bozkurt, Nisa
Duddela, Srikanth
Jansen, Rolf
Garcia, Ronald
Gerth, Klaus
Steinmetz, Heinrich
Müller, Rolf

Issue Date
2018-02-23
Metadata
Show full item recordAbstract
Some bacterial clades are important sources of novel bioactive natural products. Estimating the magnitude of chemical diversity available from such a resource is complicated by issues including cultivability, isolation bias and limited analytical data sets. Here we perform a systematic metabolite survey of ~2300 bacterial strains of the order Myxococcales, a well-established source of natural products, using mass spectrometry. Our analysis encompasses both known and previously unidentified metabolites detected under laboratory cultivation conditions, thereby enabling large-scale comparison of production profiles in relation to myxobacterial taxonomy. We find a correlation between taxonomic distance and the production of distinct secondary metabolite families, further supporting the idea that the chances of discovering novel metabolites are greater by examining strains from new genera rather than additional representatives within the same genus. In addition, we report the discovery and structure elucidation of rowithocin, a myxobacterial secondary metabolite featuring an uncommon phosphorylated polyketide scaffold.Citation
Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria. 2018, 9 (1):803 Nat CommunAffiliation
HIPS, Helmholtz-Institut für pharmazeutische Forschung Saarland, Universitätscampus 8.1, 66123 Saarbrücken, Germany.Journal
Nature communicationsPubMed ID
29476047Type
ArticleLanguage
enISSN
2041-1723ae974a485f413a2113503eed53cd6c53
10.1038/s41467-018-03184-1
Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-sa/4.0/
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