Implications of Intravital Imaging of Murine Germinal Centers on the Control of B Cell Selection and Division.

Binder, Sebastian C; Meyer-Hermann, Michael

dc.contributor.author	Binder, Sebastian C
dc.contributor.author	Meyer-Hermann, Michael
dc.date.accessioned	2018-03-14T10:27:20Z
dc.date.available	2018-03-14T10:27:20Z
dc.date.issued	2016
dc.identifier.citation	Implications of Intravital Imaging of Murine Germinal Centers on the Control of B Cell Selection and Division. 2016, 7:593 Front Immunol	en
dc.identifier.issn	1664-3224
dc.identifier.pmid	28066409
dc.identifier.doi	10.3389/fimmu.2016.00593
dc.identifier.uri	http://hdl.handle.net/10033/621322
dc.description.abstract	Intravital imaging of antibody optimization in germinal center (GC) reactions has set a new dimension in the understanding of the humoral immune response during the last decade. The inclusion of spatio-temporal cellular dynamics in the research on GCs required analysis using the agent-based mathematical models. In this study, we integrate the available intravital imaging data from various research groups and incorporate these into a quantitative mathematical model of GC reactions and antibody affinity maturation. Interestingly, the integration of data concerning the spatial organization of GCs and B cell motility allows to draw conclusions on the strength of the selection pressure and the control of B cell division by T follicular helper cells.
dc.language.iso	en	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/4.0/	*
dc.title	Implications of Intravital Imaging of Murine Germinal Centers on the Control of B Cell Selection and Division.	en
dc.type	Article	en
dc.contributor.department	BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56, 38106 Braunschweig, Germany.	en
dc.identifier.journal	Frontiers in immunology	en
refterms.dateFOA	2018-06-12T18:08:40Z
html.description.abstract	Intravital imaging of antibody optimization in germinal center (GC) reactions has set a new dimension in the understanding of the humoral immune response during the last decade. The inclusion of spatio-temporal cellular dynamics in the research on GCs required analysis using the agent-based mathematical models. In this study, we integrate the available intravital imaging data from various research groups and incorporate these into a quantitative mathematical model of GC reactions and antibody affinity maturation. Interestingly, the integration of data concerning the spatial organization of GCs and B cell motility allows to draw conclusions on the strength of the selection pressure and the control of B cell division by T follicular helper cells.