Implications of Intravital Imaging of Murine Germinal Centers on the Control of B Cell Selection and Division.
dc.contributor.author | Binder, Sebastian C | |
dc.contributor.author | Meyer-Hermann, Michael | |
dc.date.accessioned | 2018-03-14T10:27:20Z | |
dc.date.available | 2018-03-14T10:27:20Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Implications of Intravital Imaging of Murine Germinal Centers on the Control of B Cell Selection and Division. 2016, 7:593 Front Immunol | en |
dc.identifier.issn | 1664-3224 | |
dc.identifier.pmid | 28066409 | |
dc.identifier.doi | 10.3389/fimmu.2016.00593 | |
dc.identifier.uri | http://hdl.handle.net/10033/621322 | |
dc.description.abstract | Intravital imaging of antibody optimization in germinal center (GC) reactions has set a new dimension in the understanding of the humoral immune response during the last decade. The inclusion of spatio-temporal cellular dynamics in the research on GCs required analysis using the agent-based mathematical models. In this study, we integrate the available intravital imaging data from various research groups and incorporate these into a quantitative mathematical model of GC reactions and antibody affinity maturation. Interestingly, the integration of data concerning the spatial organization of GCs and B cell motility allows to draw conclusions on the strength of the selection pressure and the control of B cell division by T follicular helper cells. | |
dc.language.iso | en | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.title | Implications of Intravital Imaging of Murine Germinal Centers on the Control of B Cell Selection and Division. | en |
dc.type | Article | en |
dc.contributor.department | BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56, 38106 Braunschweig, Germany. | en |
dc.identifier.journal | Frontiers in immunology | en |
refterms.dateFOA | 2018-06-12T18:08:40Z | |
html.description.abstract | Intravital imaging of antibody optimization in germinal center (GC) reactions has set a new dimension in the understanding of the humoral immune response during the last decade. The inclusion of spatio-temporal cellular dynamics in the research on GCs required analysis using the agent-based mathematical models. In this study, we integrate the available intravital imaging data from various research groups and incorporate these into a quantitative mathematical model of GC reactions and antibody affinity maturation. Interestingly, the integration of data concerning the spatial organization of GCs and B cell motility allows to draw conclusions on the strength of the selection pressure and the control of B cell division by T follicular helper cells. |